- Father: Spitamenes, one of the leaders of the Iranian resistance against the Macedonian conquest
- Husband: Seleucus I Nicator
- Children: Antiochus I Soter
- 324: During the Susa weddings, Apame marries Seleucus, one of the officers of Alexander the Great
- Her son, Antiochus, was educated as a Greek but also learned how to rule in an Iranian fashion. For instance, like the mathišta in the Achaemenid Empire, he acted a satrap of the eastern parts of the empire, where his mother was born.
- Several cities were called after her: Apamea on the Orontes is one of these.