- Born between 285 and 280
- 260: Outbreak of the Second Syrian War. The Seleucid king Antiochus II Theos fights against Ptolemy II Philadelphus
- 253: Peace. Ptolemy II Philadelphus recognizes Seleucid territorial gains
- 252: Antiochus divorces his wife Laodice I and marries Ptolemy's daughter Berenice Phernephorus
- 251: Birth of a son Antiochus
- 28 January 246: Death of Ptolemy II; Antiochus II repudiates Berenice Phernephorus, who remains in Antioch; Antiochus returns to his first wife Laodice I
- Early July 246: Antiochus II dies in Ephesus, leaving a confused dynastic situation.
- From his marriage with Laodice I, he has two sons: Seleucus II Callinicus (immediately recognized as king) and Antiochus Hierax (co-ruler in Sardes); they live in Ephesus
- From his second marriage, with Berenice Phernephorus, he has a five-year old son Antiochus; they live in Antioch
- Late summer 246: the child Antiochus is killed by partisans of Laodice
- September 246: King Ptolemy III Euergetes decides to avenge the son of his sister: outbreak of the Laodicean War or Third Syrian War.
- He captures Seleucia and Antioch, but cannot prevent that Berenice Phernephorus is killed by the populace