Artabazus II revolted against Artaxerxes III Ochus, but was later pardoned. By then, however, Arsites had already been made satrap. During the war against Alexander the Great, this man was responsible for the Persian defeat at the Granicus river (spring 334); he committed suicide, and Alexander appointed Calas as his successor.
After Alexander's death in 323, the satrapy was awarded to Leonnatus, who was killed in action in the Lamian War. The region was seized by Lysimachus, was added to the Seleucid Empire after the battle of Corupedium (281), and was finally integrated in the Bithynian kingdom.