- Son: Nebuchadnezzar II
- After the death of the Assyrian king Aššurbanipal in 631, the situation was confused, and the Babylonians revolted against their two Assyrian governors, Sin-šum-lišir and Sin-šar-iškun. The rebels defeated an Assyrian army, and the Babylonian general Nabopolassar was recognized as king on 23 November 626.
- 625: Battle of Raqmat; after a victory, Nabopolassar retreats
- 624: Inconclusive fighting near the Banitu Canal
- 623: Fighting in Der
- 616: Nabopolassar defeats the Assyrians near Gablini
- 615: Winter: Babylonian victory at Arraphu; fighting at Takrita'in
- 614: Sack of Aššur; rendez-vous between Nabopolassar and the Median leader Cyaxares. According to Berossus, Nebuchadnezzar marries the Median princess Amytis.
- 612: Sack of Nineveh; continued war
- 610: Capture of Harran
- 608: Campaign against Urartu
- 607: Campaign against Kimuhu (Commagene); Nebuchadnezzar campaigns in Biranati
- 605: Nebuchadnezzar, the crown prince, defeats the Egyptian king Necho at Karchemiš
- August 605: Death of Nabopolassar; Nebuchadnezzar becomes king
Succeeded by: his son Nebuchadnezzar II