Artystone's marriage to Darius the Great, briefly after his coup d'état in 521 BCE, was important because it connected two lines of the Achaemenid dynasty, which was necessary because the elder branch had died out and Darius belonged to the younger branch. A similar marriage was concluded between Darius and Artystone's elder sister Atossa.
According to the Greek researcher Herodotus of Halicarnassus, Artystone was Darius' favorite wife; he erected a golden statue of her.note[Herodotus, Histories 7.69.] The couple had three children: Arsames, Gobryas, and Artozostre.
In the Persepolis Fortification Tablets, this queen is called Irtašduna. She appears to have been one of the most influential women at the Achaemenid court, and owned large estates in Persis.