- Laodice was the first wife of the Seleucid king Antiochus II. They had several children, listed above
- 252: After the Second Syrian War, Antiochus II married to a daughter of Ptolemy II Philadelphus, Berenice Phernephorus; they have a son, Antiochus
- Laodice, although no longer a queen, retains possessions near Cyzicus
- 28 January 246: Death of Ptolemy II; Antiochus II repudiates Berenice, who stays in Antioch; Antiochus returns to his first wife Laodice I
- Early July 246: Antiochus II dies in Ephesus, leaving a confused dynastic situation.
- From his marriage with Laodice, he has two sons: Seleucus II Callinicus (immediately recognized as king) and Antiochus Hierax (co-ruler in Sardes); they live in Ephesus
- From his second marriage, with Berenice, he has a five-year old son Antiochus; they live in Antioch
- Late summer 246: the child Antiochus is killed by partisans of Laodice
- September 246: King Ptolemy III Euergetes decides to avenge the son of his sister: outbreak of the Laodicean War or Third Syrian War.
- He captures Seleucia and Antioch, but cannot prevent that Berenice is killed by the populace
- December 246: Ptolemy proceeds to Babylon; he is still there in February 245, but is forced to return
- 245: "Laodice" marries Mithridates II of Pontus; Phrygia is awarded to him as a marriage gift
- During the reign of Seleucus II Callinicus, Laodice supports the revolt of Antiochus Hierax
- Laodice appears to have died before 236
- O.L. Gabelko & Yu.N. Kuzmin, "Matrimonial Policy of Demetrius II of Macedonia. New Solutions of Old Problems", in: Vestnik drevnej istorii 264 (2008) 141-164