In 114 CE, war broke out between the Parthian and the Roman empires. The Roman emperor Trajan successfully conquered Armenia, occupied Edessa and Nisibis in the next year, and added Babylon, Ctesiphon and Seleucia in 116. The Parthian king Osroes I could do next to nothing, but there were anti-Roman rebellions. In Armenia, the rebel leader was a man named Sanatruces; in the south, an Arsacid prince named Mithradates V, a relative of Osroes. At the same time, the diasporic Jews revolted in Cyrenaica and on Cyprus, forcing Trajan to send troops to suppress them (more).
Although Trajan overcame all troubles, he died soon after. His successor Hadrian gave up the territories that had been conquered. Sanatruces' fate is not known.